Fitness of unregulated human Ras mutants modeled by implementing computational mutagenesis and machine learning techniques

Ras proteins play a pivotal role as oncogenes by participating in diverse signaling events, including those linked to cell growth, differentiation, and proliferation. Using experimental fitness data and implementing artificial intelligence and a computational mutagenesis technique, we developed mode...

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Detalles Bibliográficos
Autores principales: Masso, Majid, Bansal, Arnav, Prem, Preethi, Gajjala, Akhil, Vaisman, Iosif I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562371/
https://www.ncbi.nlm.nih.gov/pubmed/31211262
http://dx.doi.org/10.1016/j.heliyon.2019.e01884

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562371/
https://www.ncbi.nlm.nih.gov/pubmed/31211262
http://dx.doi.org/10.1016/j.heliyon.2019.e01884

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