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Fitness of unregulated human Ras mutants modeled by implementing computational mutagenesis and machine learning techniques
Ras proteins play a pivotal role as oncogenes by participating in diverse signaling events, including those linked to cell growth, differentiation, and proliferation. Using experimental fitness data and implementing artificial intelligence and a computational mutagenesis technique, we developed mode...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562371/ https://www.ncbi.nlm.nih.gov/pubmed/31211262 http://dx.doi.org/10.1016/j.heliyon.2019.e01884 |