Mutant p53, Stabilized by Its Interplay with HSP90, Activates a Positive Feed-Back Loop Between NRF2 and p62 that Induces Chemo-Resistance to Apigenin in Pancreatic Cancer Cells

Pancreatic cancer is one of the most aggressive cancers whose prognosis is worsened by the poor response to the current chemotherapies. In this study, we investigated the cytotoxic effect of Apigenin, against two pancreatic cell lines, namely Panc1 and PaCa44, harboring different p53 mutations. Apig...

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Detalles Bibliográficos
Autores principales: Gilardini Montani, Maria Saveria, Cecere, Nives, Granato, Marisa, Romeo, Maria Anele, Falcinelli, Luca, Ciciarelli, Umberto, D’Orazi, Gabriella, Faggioni, Alberto, Cirone, Mara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562395/
https://www.ncbi.nlm.nih.gov/pubmed/31121848
http://dx.doi.org/10.3390/cancers11050703

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562395/
https://www.ncbi.nlm.nih.gov/pubmed/31121848
http://dx.doi.org/10.3390/cancers11050703

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