MDM2-Mediated p21 Proteasomal Degradation Promotes Fluoride Toxicity in Ameloblasts

Fluoride overexposure is an environmental health hazard and can cause enamel and skeletal fluorosis. Previously we demonstrated that fluoride increased acetylated-p53 and its downstream target p21 in ameloblast-derived LS8 cells. However, p21 function in fluoride toxicity is not well characterized....

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Detalles Bibliográficos
Autores principales: Deng, Huidan, Ikeda, Atsushi, Cui, Hengmin, Bartlett, John D., Suzuki, Maiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562432/
https://www.ncbi.nlm.nih.gov/pubmed/31083332
http://dx.doi.org/10.3390/cells8050436

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562432/
https://www.ncbi.nlm.nih.gov/pubmed/31083332
http://dx.doi.org/10.3390/cells8050436

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