A Comparison of DNA Mutation and Copy Number Profiles of Primary Breast Cancers and Paired Brain Metastases for Identifying Clinically Relevant Genetic Alterations in Brain Metastases

Improving the systemic treatment of brain metastases (BM) in primary breast cancer (PBC) is impaired by the lack of genomic characterization of BM. To estimate the concordance of DNA copy-number-alterations (CNAs), mutations, and actionable genetic alterations (AGAs) between paired samples, we perfo...

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Detalles Bibliográficos
Autores principales: Tyran, Marguerite, Carbuccia, Nadine, Garnier, Séverine, Guille, Arnaud, Adelaïde, José, Finetti, Pascal, Touzlian, Julien, Viens, Patrice, Tallet, Agnès, Goncalves, Anthony, Metellus, Philippe, Birnbaum, Daniel, Chaffanet, Max, Bertucci, François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562582/
https://www.ncbi.nlm.nih.gov/pubmed/31086113
http://dx.doi.org/10.3390/cancers11050665

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562582/
https://www.ncbi.nlm.nih.gov/pubmed/31086113
http://dx.doi.org/10.3390/cancers11050665

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