Inhibition of Hedgehog Signaling in Fibroblasts, Pancreatic, and Lung Tumor Cells by Oxy186, an Oxysterol Analogue with Drug-Like Properties

The widespread involvement of the Hedgehog (Hh) signaling pathway in human malignancies has motivated the clinical development of Smoothened (Smo) antagonists, such as vismodegib and sonidegib. However, Smo antagonists have failed to benefit patients suffering from Hh pathway-dependent solid tumors,...

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Detalles Bibliográficos
Autores principales: Wang, Feng, Stappenbeck, Frank, Parhami, Farhad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562610/
https://www.ncbi.nlm.nih.gov/pubmed/31137846
http://dx.doi.org/10.3390/cells8050509

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562610/
https://www.ncbi.nlm.nih.gov/pubmed/31137846
http://dx.doi.org/10.3390/cells8050509

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