Effects of Copper Chelation on BRAF(V600E) Positive Colon Carcinoma Cells

High affinity copper binding to mitogen-activated protein kinase kinase 1 (MAP2K1, also known as MEK1) allosterically promotes the kinase activity of MEK1/2 on extracellular signal regulated kinases 1 and 2 (ERK1/2). Consequently, copper-dependent activation of the mitogen-activated (MAP) kinase pat...

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Detalles Bibliográficos
Autores principales: Baldari, Silvia, Di Rocco, Giuliana, Heffern, Marie C., Su, Timothy A., Chang, Christopher J., Toietta, Gabriele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562624/
https://www.ncbi.nlm.nih.gov/pubmed/31083627
http://dx.doi.org/10.3390/cancers11050659

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562624/
https://www.ncbi.nlm.nih.gov/pubmed/31083627
http://dx.doi.org/10.3390/cancers11050659

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