Cargando…

Recent Advances in the Clinical Targeting of Hedgehog/GLI Signaling in Cancer

The Hedgehog/GLI signaling pathway plays an important role in normal embryonic tissue development and has been implicated in the pathogenesis of various human cancers. In this review article, we summarize pre-clinical evidence supporting the suitability of targeting this signaling pathway in cancers...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xie, Hao, Paradise, Brooke D., Ma, Wen Wee, Fernandez-Zapico, Martin E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562674/ https://www.ncbi.nlm.nih.gov/pubmed/31035664 http://dx.doi.org/10.3390/cells8050394

Ejemplares similares

Hedgehog/GLI Signaling Pathway: Transduction, Regulation, and Implications for Disease
por: Sigafoos, Ashley N., et al.
Publicado: (2021)

Targeting non-canonical activation of GLI1 by the SOX2-BRD4 transcriptional complex improves the efficacy of HEDGEHOG pathway inhibition in melanoma
por: Pietrobono, Silvia, et al.
Publicado: (2021)

Hedgehog Signaling and Truncated GLI1 in Cancer
por: Doheny, Daniel, et al.
Publicado: (2020)

Targeting Epigenetic Aberrations in Pancreatic Cancer, a New Path to Improve Patient Outcomes?
por: Paradise, Brooke D., et al.
Publicado: (2018)

Gli2, hedgehog and TCR signalling
por: Furmanski, Anna L., et al.
Publicado: (2015)

Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors
por: Rimkus, Tadas K., et al.
Publicado: (2016)

Synergism between Hedgehog-GLI and EGFR Signaling in Hedgehog-Responsive Human Medulloblastoma Cells Induces Downregulation of Canonical Hedgehog-Target Genes and Stabilized Expression of GLI1
por: Götschel, Frank, et al.
Publicado: (2013)

Gli Phosphorylation Code in Hedgehog Signal Transduction
por: Zhou, Mengmeng, et al.
Publicado: (2022)

The therapeutic potential of modulators of the Hedgehog-Gli signaling pathway
por: Stecca, Barbara, et al.
Publicado: (2002)

Hedgehog and Gli Signaling in Embryonic Mammary Gland Development
por: Lee, May Yin, et al.
Publicado: (2013)

Gli inhibitor pricked by Hedgehog
por: Short, Ben
Publicado: (2010)

Acute myeloid leukemia – strategies and challenges for targeting oncogenic Hedgehog/GLI signaling
por: Aberger, Fritz, et al.
Publicado: (2017)

Attenuation of hedgehog/GLI signaling by NT1721 extends survival in pancreatic cancer
por: Kowolik, Claudia M., et al.
Publicado: (2019)

Hedgehog/GLI signaling in tumor immunity - new therapeutic opportunities and clinical implications
por: Grund-Gröschke, Sandra, et al.
Publicado: (2019)

TFII-I-mediated polymerase pausing antagonizes GLI2 induction by TGFβ
por: McCleary-Wheeler, Angela L, et al.
Publicado: (2020)

Survivin, a novel target of the Hedgehog/GLI signaling pathway in human tumor cells
por: Vlčková, K, et al.
Publicado: (2016)

The GLI genes as the molecular switch in disrupting Hedgehog signaling in colon cancer
por: Mazumdar, Tapati, et al.
Publicado: (2011)

GLI1 finds a new role in cancer stem cell biology
por: Fernandez-Zapico, Martin E
Publicado: (2013)

Hedgehog/GLI1 signaling pathway regulates the resistance to cisplatin in human osteosarcoma
por: Chen, Daosen, et al.
Publicado: (2021)

Hippo signaling activates hedgehog signaling by Taz-driven Gli3 processing
por: Tang, Chao, et al.
Publicado: (2023)

Lithium Inhibits Tumorigenic Potential of PDA Cells through Targeting Hedgehog-GLI Signaling Pathway
por: Peng, Zhonglu, et al.
Publicado: (2013)

Maintenance of Taste Organs Is Strictly Dependent on Epithelial Hedgehog/GLI Signaling
por: Ermilov, Alexandre N., et al.
Publicado: (2016)

Structural basis of SUFU–GLI interaction in human Hedgehog signalling regulation
por: Cherry, Amy L., et al.
Publicado: (2013)

Defining the Role of GLI/Hedgehog Signaling in Chemoresistance: Implications in Therapeutic Approaches
por: Chai, Jian Yi, et al.
Publicado: (2021)

Tamoxifen Treatment of Breast Cancer Cells: Impact on Hedgehog/GLI1 Signaling
por: Villegas, Victoria E., et al.
Publicado: (2016)

Non-consensus GLI binding sites in Hedgehog target gene regulation
por: Winklmayr, Martina, et al.
Publicado: (2010)

Developmental pathways: Sonic hedgehog-Patched-GLI.
por: Walterhouse, D O, et al.
Publicado: (1999)

PANCREATIC CANCER PROLIFERATION IS INDUCED BY GLI2-COL1 SIGNALING IN FIBROBLASTS IN THE TUMOR MICROENVIRONMENT
por: Ross, Madeline, et al.
Publicado: (2022)

SPOP suppresses tumorigenesis by regulating Hedgehog/Gli2 signaling pathway in gastric cancer
por: Zeng, Chunyan, et al.
Publicado: (2014)

RNA editing of the GLI1 transcription factor modulates the output of Hedgehog signaling
por: Shimokawa, Takashi, et al.
Publicado: (2013)

Investigating the role of Hedgehog/GLI1 signaling in glioblastoma cell response to temozolomide
por: Melamed, Jilian R., et al.
Publicado: (2018)

Targeting the hedgehog transcription factors GLI1 and GLI2 restores sensitivity to vemurafenib-resistant human melanoma cells
por: Faião-Flores, F, et al.
Publicado: (2017)

β(2)‐adrenergic receptor signaling drives prostate cancer progression by targeting the Sonic hedgehog‐Gli1 signaling activation
por: Zhang, Mi, et al.
Publicado: (2020)

ST3GAL1 is a target of the SOX2-GLI1 transcriptional complex and promotes melanoma metastasis through AXL
por: Pietrobono, Silvia, et al.
Publicado: (2020)

Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors
por: Infante, Paola, et al.
Publicado: (2015)

Next-Generation Hedgehog/GLI Pathway Inhibitors for Cancer Therapy
por: Peer, Elisabeth, et al.
Publicado: (2019)

Sonic Hedgehog factor Gli1: As good as resistant
por: Zahreddine, Hiba Ahmad, et al.
Publicado: (2015)

Hedgehog-GLI mediated control of renal formation and malformation
por: Greenberg, Dina, et al.
Publicado: (2023)

Targeting hedgehog signaling in cancer: research and clinical developments
por: Xie, Jingwu, et al.
Publicado: (2013)

Sonic hedgehog through Gli2 and Gli3 is required for the proper development of placental labyrinth
por: Pan, Y B, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_cmjbadic6ekghcaiv5iedaoset