Cargando…

Tumour-Derived Laminin α5 (LAMA5) Promotes Colorectal Liver Metastasis Growth, Branching Angiogenesis and Notch Pathway Inhibition

Hepatic metastatic growth is dependent upon stromal factors including the matrisomal proteins that make up the extracellular matrix (ECM). Laminins are ECM glycoproteins with several functions relevant to tumour progression including angiogenesis. We investigated whether metastatic colon cancer cell...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gordon-Weeks, Alex, Lim, Su Yin, Yuzhalin, Arseniy, Lucotti, Serena, Vermeer, Jenny Adriana Francisca, Jones, Keaton, Chen, Jianzhou, Muschel, Ruth J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562694/ https://www.ncbi.nlm.nih.gov/pubmed/31064120 http://dx.doi.org/10.3390/cancers11050630

Ejemplares similares

Transgenic Expression of Human LAMA5 Suppresses Murine Lama5 mRNA and Laminin α5 Protein Deposition
por: Steenhard, Brooke M., et al.
Publicado: (2011)

Cancer Extracellular Matrix Proteins Regulate Tumour Immunity
por: Gordon-Weeks, Alex, et al.
Publicado: (2020)

Targeting the CCL2-CCR2 signaling axis in cancer metastasis
por: Lim, Su Yin, et al.
Publicado: (2016)

Radiation combined with macrophage depletion promotes adaptive immunity and potentiates checkpoint blockade
por: Jones, Keaton I, et al.
Publicado: (2018)

A core matrisome gene signature predicts cancer outcome
por: Yuzhalin, Arseniy E, et al.
Publicado: (2018)

Platelets and Metastasis: New Implications of an Old Interplay
por: Lucotti, Serena, et al.
Publicado: (2020)

Association of variation in the LAMA3 gene, encoding the alpha-chain of laminin 5, with atopic dermatitis in a German case–control cohort
por: Stemmler, Susanne, et al.
Publicado: (2014)

Laminin and Integrin in LAMA2-Related Congenital Muscular Dystrophy: From Disease to Therapeutics
por: Barraza-Flores, Pamela, et al.
Publicado: (2020)

Human laminin-111 and laminin-211 protein therapy prevents muscle disease progression in an immunodeficient mouse model of LAMA2-CMD
por: Barraza-Flores, Pamela, et al.
Publicado: (2020)

FGF2 alters macrophage polarization, tumour immunity and growth and can be targeted during radiotherapy
por: Im, Jae Hong, et al.
Publicado: (2020)

Proteomics analysis of the matrisome from MC38 experimental mouse liver metastases
por: Yuzhalin, Arseniy E., et al.
Publicado: (2019)

Tumor-infiltrating monocytes/macrophages promote tumor invasion and migration by upregulating S100A8 and S100A9 expression in cancer cells
por: Lim, S Y, et al.
Publicado: (2016)

Transformed MDCK cells secrete elevated MMP1 that generates LAMA5 fragments promoting endothelial cell angiogenesis
por: Gopal, Shashi K., et al.
Publicado: (2016)

A Family of Laminin α2 Chain-Deficient Mouse Mutants: Advancing the Research on LAMA2-CMD
por: Gawlik, Kinga I., et al.
Publicado: (2020)

Type I IFN protects cancer cells from CD8(+) T cell–mediated cytotoxicity after radiation
por: Chen, Jianzhou, et al.
Publicado: (2019)

Amelioration of muscle and nerve pathology of Lama2-related dystrophy by AAV9-laminin-αLN linker protein
por: McKee, Karen K., et al.
Publicado: (2022)

VEGF and Delta-Notch: interacting signalling pathways in tumour angiogenesis
por: Thurston, G, et al.
Publicado: (2008)

Non-canonical NOTCH3 signalling limits tumour angiogenesis
por: Lin, Shuheng, et al.
Publicado: (2017)

Deletion of exon 4 in LAMA2 is the most frequent mutation in Chinese patients with laminin α2-related muscular dystrophy
por: Ge, Lin, et al.
Publicado: (2018)

Recessive LAMA5 Variants Associated With Partial Epilepsy and Spasms in Infancy
por: Luo, Sheng, et al.
Publicado: (2022)

Dalai Lama
Publicado: (2020)

Dalaï-Lama
Publicado: (2020)

Lamas in loops
por: Lai, Eric C.
Publicado: (2003)

Tumor cell α(3)β(1) integrin and vascular laminin-5 mediate pulmonary arrest and metastasis
por: Wang, Hui, et al.
Publicado: (2004)

Roles for Laminin in Embryogenesis: Exencephaly, Syndactyly, and Placentopathy in Mice Lacking the Laminin α5 Chain
por: Miner, Jeffrey H., et al.
Publicado: (1998)

Dalai Lama at CERN
Publicado: (1983)

Visit of Dalay Lama
Publicado: (1983)

Human amnion contains a novel laminin variant, laminin 7, which like laminin 6, covalently associates with laminin 5 to promote stable epithelial-stromal attachment
Publicado: (1996)

Expression of laminin 5-γ2 chain in cutaneous squamous cell carcinoma and its role in tumour invasion
por: Hamasaki, H, et al.
Publicado: (2011)

Laminin α5 guides tissue patterning and organogenesis
por: Spenlé, Caroline, et al.
Publicado: (2013)

Laminin-5 is a biomarker of invasiveness in cervical adenocarcinoma
por: Imura, Johji, et al.
Publicado: (2012)

A lineage-tracing tool to map the fate of hypoxic tumour cells
por: Vermeer, Jenny A. F., et al.
Publicado: (2020)

Contribution of Endothelial Laminin-Binding Integrins to Cellular Processes Associated with Angiogenesis
por: Xu, Hao, et al.
Publicado: (2022)

Dalai Lama comes to CERN
Publicado: (1983)

A Conversation with the Grand Lama
Publicado: (1889)

Abnormal Wnt and PI3Kinase Signaling in the Malformed Intestine of lama5 Deficient Mice
por: Ritié, Léa, et al.
Publicado: (2012)

CNS Neurons Deposit Laminin α5 to Stabilize Synapses
por: Omar, Mitchell H., et al.
Publicado: (2017)

COL4A5 and LAMA5 variants co-inherited in familial hematuria: digenic inheritance or genetic modifier effect?
por: Voskarides, Konstantinos, et al.
Publicado: (2018)

Critical functions of extracellular matrix in brain metastasis seeding
por: Yuzhalin, Arseniy E., et al.
Publicado: (2023)

La sabiduría del Dalai Lama /
por: Dalai Lama XIV, 1935-
Publicado: (1999)

Cannot write session to /tmp/vufind_sessions/sess_n5knhf7vn4sojpbkm66sik57o7