pHluorin-BACE1-mCherry Acts as a Reporter for the Intracellular Distribution of Active BACE1 In Vitro and In Vivo

β-site APP-cleaving enzyme 1 (BACE1) initiates amyloid precursor protein (APP) cleavage and β-amyloid (Aβ) production, a critical step in the pathogenesis of Alzheimer’s disease (AD). It is thus of considerable interest to investigate how BACE1 activity is regulated. BACE1 has its maximal activity a...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhao, Lu, Zhao, Yang, Tang, Fu-Lei, Xiong, Lei, Su, Ce, Mei, Lin, Zhu, Xiao-Juan, Xiong, Wen-Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562731/
https://www.ncbi.nlm.nih.gov/pubmed/31108937
http://dx.doi.org/10.3390/cells8050474

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562731/
https://www.ncbi.nlm.nih.gov/pubmed/31108937
http://dx.doi.org/10.3390/cells8050474

Ejemplares similares