Cargando…

Targeting Endometrial Cancer Stem Cell Activity with Metformin Is Inhibited by Patient-Derived Adipocyte-Secreted Factors

Advanced endometrial cancer continues to have a poor prognosis, due to limited treatment options, which may be further adversely impacted by obesity. Endometrial cancer stem cells have been reported to drive metastasis, chemotherapy resistance and disease relapse, but have yet to be fully characteri...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kitson, Sarah J., Rosser, Matthew, Fischer, Deborah P., Marshall, Kay M., Clarke, Robert B., Crosbie, Emma J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562824/ https://www.ncbi.nlm.nih.gov/pubmed/31083574 http://dx.doi.org/10.3390/cancers11050653

Ejemplares similares

Hypoxia and hyperglycaemia determine why some endometrial tumours fail to respond to metformin
por: Sivalingam, Vanitha N., et al.
Publicado: (2019)

Measuring the biological effect of presurgical metformin treatment in endometrial cancer
por: Sivalingam, V N, et al.
Publicado: (2016)

Optimization of Window Study Endpoints in Endometrial Cancer
por: Kitson, Sarah J., et al.
Publicado: (2019)

Metformin Inhibits Expression and Secretion of PEDF in Adipocyte and Hepatocyte via Promoting AMPK Phosphorylation
por: Yang, Shumin, et al.
Publicado: (2013)

High prevalence of metabolic syndrome in women newly diagnosed with endometrial cancer
por: Kitson, Sarah J., et al.
Publicado: (2018)

Derivation of Adipocytes from Human Endometrial Stem Cells (EnSCs)
por: Ai, Jafar, et al.
Publicado: (2012)

Monocarboxylate Transporter 1 (MCT1) is an independent prognostic biomarker in endometrial cancer
por: Latif, Ayşe, et al.
Publicado: (2017)

Metabolomic Biomarkers for the Detection of Obesity-Driven Endometrial Cancer
por: Njoku, Kelechi, et al.
Publicado: (2021)

Prevention Strategies in Endometrial Carcinoma
por: MacKintosh, Michelle L., et al.
Publicado: (2018)

Iron Inhibits the Secretion of Apolipoprotein E in Cultured Human Adipocytes
por: Britton, L.J., et al.
Publicado: (2018)

The unrecognized burden of cardiovascular risk factors in women newly diagnosed with endometrial cancer: A prospective case control study
por: Kitson, Sarah J., et al.
Publicado: (2018)

BRCA1 and BRCA2 pathogenic variant carriers and endometrial cancer risk: A cohort study
por: Kitson, Sarah J., et al.
Publicado: (2020)

Bone marrow adipocytes promote the regeneration of stem cells and hematopoiesis by secreting SCF
por: Zhou, Bo O., et al.
Publicado: (2017)

HE4 as a Biomarker for Endometrial Cancer
por: Behrouzi, Roya, et al.
Publicado: (2021)

Current and Emerging Prognostic Biomarkers in Endometrial Cancer
por: Njoku, Kelechi, et al.
Publicado: (2022)

High Glucose-Mediated STAT3 Activation in Endometrial Cancer Is Inhibited by Metformin: Therapeutic Implications for Endometrial Cancer
por: Wallbillich, John J., et al.
Publicado: (2017)

Proteomic Biomarkers for the Detection of Endometrial Cancer
por: Njoku, Kelechi, et al.
Publicado: (2019)

Obesity and the Endometrium: Adipocyte-Secreted Proinflammatory TNFα Cytokine Enhances the Proliferation of Human Endometrial Glandular Cells
por: Nair, Sangeeta, et al.
Publicado: (2013)

Metformin promotes angiogenesis by enhancing VEGFa secretion by adipose-derived stem cells via the autophagy pathway
por: Tao, Zihan, et al.
Publicado: (2023)

Collagen overlays can inhibit leptin and adiponectin secretion but not lipid accumulation in adipocytes
por: Christian, Sherri L., et al.
Publicado: (2018)

Adipocyte-derived Stem Cells in Facial Surgery
por: Balaji, S. M.
Publicado: (2022)

Metformin as a Therapeutic Target in Endometrial Cancers
por: Lee, Teresa Y., et al.
Publicado: (2018)

Nicotinamide Riboside Improves Stemness of Human Adipose-Derived Stem Cells and Inhibits Terminal Adipocyte Differentiation
por: Chinnapaka, Somaiah, et al.
Publicado: (2023)

Isoliquiritigenin Enhances the Beige Adipocyte Potential of Adipose-Derived Stem Cells by JNK Inhibition
por: Moon, Hanbyeol, et al.
Publicado: (2020)

Polygenic risk score opportunities for early detection and prevention strategies in endometrial cancer
por: O’Mara, Tracy A., et al.
Publicado: (2020)

Oncostatin M Mediates Adipocyte Expression and Secretion of Stromal-Derived Factor 1
por: Hang, Hardy, et al.
Publicado: (2019)

Interleukin-1β Downregulates RBP4 Secretion in Human Adipocytes
por: Kotnik, Primoz, et al.
Publicado: (2013)

Metformin limits the adipocyte tumor-promoting effect on ovarian cancer
por: Tebbe, Calvin, et al.
Publicado: (2014)

Secreted Nucleobindin-2 Inhibits 3T3-L1 Adipocyte Differentiation
por: Tagaya, Yuko, et al.
Publicado: (2012)

Metformin for endometrial hyperplasia: a Cochrane protocol
por: Clement, Naomi S, et al.
Publicado: (2016)

Metabolomic Biomarkers for Detection, Prognosis and Identifying Recurrence in Endometrial Cancer
por: Njoku, Kelechi, et al.
Publicado: (2020)

Metformin inhibits growth and prolactin secretion of pituitary prolactinoma cells and xenografts
por: Gao, Jun, et al.
Publicado: (2018)

Impact of Type 2 Diabetes Mellitus on Endometrial Cancer Survival: A Prospective Database Analysis
por: Njoku, Kelechi, et al.
Publicado: (2022)

Cost-Effectiveness of the Manchester Approach to Identifying Lynch Syndrome in Women with Endometrial Cancer
por: Snowsill, Tristan M., et al.
Publicado: (2020)

Ki-67 in endometrial cancer: scoring optimization and prognostic relevance for window studies
por: Kitson, Sarah, et al.
Publicado: (2017)

Association between genetic polymorphisms and endometrial cancer risk: a systematic review
por: Bafligil, Cemsel, et al.
Publicado: (2020)

Inhibition of γ-secretase in adipocytes leads to altered IL-6 secretion and adipose inflammation
por: Sparling, David P., et al.
Publicado: (2020)

Dynamics of protein secretion during adipocyte differentiation
por: Ojima, Koichi, et al.
Publicado: (2016)

Metformin, an AMPK Activator, Inhibits Activation of FLSs but Promotes HAPLN1 Secretion
por: Chen, Yong, et al.
Publicado: (2020)

Metformin Regulates TET2 Expression to Inhibit Endometrial Carcinoma Proliferation: A New Mechanism
por: Zhang, Jingbo, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_qmm01gatm0rfumbeo39gp0j4vc