Arming T Cells with a gp100-Specific TCR and a CSPG4-Specific CAR Using Combined DNA- and RNA-Based Receptor Transfer

Tumor cells can develop immune escape mechanisms to bypass T cell recognition, e.g., antigen loss or downregulation of the antigen presenting machinery, which represents a major challenge in adoptive T cell therapy. To counteract these mechanisms, we transferred not only one, but two receptors into...

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Detalles Bibliográficos
Autores principales: Simon, Bianca, Harrer, Dennis C., Schuler-Thurner, Beatrice, Schuler, Gerold, Uslu, Ugur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562862/
https://www.ncbi.nlm.nih.gov/pubmed/31137488
http://dx.doi.org/10.3390/cancers11050696

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562862/
https://www.ncbi.nlm.nih.gov/pubmed/31137488
http://dx.doi.org/10.3390/cancers11050696

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