Modulating PKCα Activity to Target Wnt/β-Catenin Signaling in Colon Cancer

Inactivating mutations of the tumor suppressor Adenomatosis Polyposis Coli (APC), which are found in familial adenomatosis polyposis and in 80% of sporadic colorectal cancers (CRC), result in constitutive activation of the Wnt/β-catenin pathway and tumor development in the intestine. These mutations...

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Detalles Bibliográficos
Autores principales: Dupasquier, Sébastien, Blache, Philippe, Picque Lasorsa, Laurence, Zhao, Han, Abraham, Jean-Daniel, Haigh, Jody J., Ychou, Marc, Prévostel, Corinne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563011/
https://www.ncbi.nlm.nih.gov/pubmed/31109112
http://dx.doi.org/10.3390/cancers11050693

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563011/
https://www.ncbi.nlm.nih.gov/pubmed/31109112
http://dx.doi.org/10.3390/cancers11050693

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