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Detecting and Tracking Circulating Tumour DNA Copy Number Profiles during First Line Chemotherapy in Oesophagogastric Adenocarcinoma
DNA somatic copy number aberrations (SCNAs) are key drivers in oesophagogastric adenocarcinoma (OGA). Whether minimally invasive SCNA analysis of circulating tumour (ct)DNA can predict treatment outcomes and reveal how SCNAs evolve during chemotherapy is unknown. We investigated this by low-coverage...
Autores principales: | Davidson, Michael, Barber, Louise J., Woolston, Andrew, Cafferkey, Catherine, Mansukhani, Sonia, Griffiths, Beatrice, Moorcraft, Sing-Yu, Rana, Isma, Begum, Ruwaida, Assiotis, Ioannis, Matthews, Nik, Rao, Sheela, Watkins, David, Chau, Ian, Cunningham, David, Starling, Naureen, Gerlinger, Marco |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563045/ https://www.ncbi.nlm.nih.gov/pubmed/31137920 http://dx.doi.org/10.3390/cancers11050736 |
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