CAR T-Cells Targeting the Integrin αvβ6 and Co-Expressing the Chemokine Receptor CXCR2 Demonstrate Enhanced Homing and Efficacy against Several Solid Malignancies

Despite the unprecedented clinical success of chimeric antigen receptors (CAR) T-cells against haematological malignancy, solid tumors impose a far greater challenge to success. Largely, this stems from an inadequate capacity of CAR T-cells that can traffic and maintain function within a hostile mic...

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Detalles Bibliográficos
Autores principales: Whilding, Lynsey M., Halim, Leena, Draper, Benjamin, Parente-Pereira, Ana C., Zabinski, Tomasz, Davies, David Marc, Maher, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563120/
https://www.ncbi.nlm.nih.gov/pubmed/31091832
http://dx.doi.org/10.3390/cancers11050674

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563120/
https://www.ncbi.nlm.nih.gov/pubmed/31091832
http://dx.doi.org/10.3390/cancers11050674

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