Cargando…

Telomere Gene Therapy: Polarizing Therapeutic Goals for Treatment of Various Diseases

Modulation of telomerase maintenance by gene therapy must meet two polarizing requirements to achieve different therapeutic outcomes: Anti-aging/regenerative applications require upregulation, while anticancer applications necessitate suppression of various genes integral to telomere maintenance (e....

Descripción completa

Detalles Bibliográficos
Autores principales:	Hong, JinWoo, Yun, Chae-Ok
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563133/ https://www.ncbi.nlm.nih.gov/pubmed/31035374 http://dx.doi.org/10.3390/cells8050392

Ejemplares similares

Overcoming the limitations of locally administered oncolytic virotherapy
por: Hong, JinWoo, et al.
Publicado: (2019)

Challenges and progress toward tumor-targeted therapy by systemic delivery of polymer-complexed oncolytic adenoviruses
por: Thambi, Thavasyappan, et al.
Publicado: (2022)

Regulatory T Cells Induce Metastasis by Activating Tgf-Β and Enhancing the Epithelial–Mesenchymal Transition
por: Oh, Eonju, et al.
Publicado: (2019)

Adenovirus-mediated decorin expression induces cancer cell death through activation of p53 and mitochondrial apoptosis
por: Yoon, A-Rum, et al.
Publicado: (2017)

Oncolytic adenovirus coexpressing interleukin-12 and shVEGF restores antitumor immune function and enhances antitumor efficacy
por: Ahn, Hyo Min, et al.
Publicado: (2016)

Oncolytic Viruses and Immune Checkpoint Inhibitors: Preclinical Developments to Clinical Trials
por: Hwang, June Kyu, et al.
Publicado: (2020)

Current clinical landscape of oncolytic viruses as novel cancer immunotherapeutic and recent preclinical advancements
por: Yun, Chae-Ok, et al.
Publicado: (2022)

Hepatocellular carcinoma-targeting oncolytic adenovirus overcomes hypoxic tumor microenvironment and effectively disperses through both central and peripheral tumor regions
por: Yoon, A-Rum, et al.
Publicado: (2018)

A hypoxia- and telomerase-responsive oncolytic adenovirus expressing secretable trimeric TRAIL triggers tumour-specific apoptosis and promotes viral dispersion in TRAIL-resistant glioblastoma
por: Oh, Eonju, et al.
Publicado: (2018)

Oncolytic adenovirus coexpressing interleukin-12 and decorin overcomes Treg-mediated immunosuppression inducing potent antitumor effects in a weakly immunogenic tumor model
por: Oh, Eonju, et al.
Publicado: (2016)

A vesicular stomatitis virus glycoprotein epitope-incorporated oncolytic adenovirus overcomes CAR-dependency and shows markedly enhanced cancer cell killing and suppression of tumor growth
por: Yoon, A-Rum, et al.
Publicado: (2015)

Telomere-driven diseases and telomere-targeting therapies
por: Martínez, Paula, et al.
Publicado: (2017)

Mortalin deficiency suppresses fibrosis and induces apoptosis in keloid spheroids
por: Lee, Won Jai, et al.
Publicado: (2017)

GM101 in Combination with Histone Deacetylase Inhibitor Enhances Anti-Tumor Effects in Desmoplastic Microenvironment
por: Chang, Han-Gyu, et al.
Publicado: (2021)

Telomeres as Therapeutic Targets in Heart Disease
por: Yeh, Jih-Kai, et al.
Publicado: (2019)

ErbB3-Targeting Oncolytic Adenovirus Causes Potent Tumor Suppression by Induction of Apoptosis in Cancer Cells
por: Jung, Bo-Kyeong, et al.
Publicado: (2022)

Combination Therapy for Hypothyroidism: Rationale, Therapeutic Goals, and Design
por: Madan, Ritu, et al.
Publicado: (2020)

Decoy Wnt receptor (sLRP6E1E2)-expressing adenovirus induces anti-fibrotic effect via inhibition of Wnt and TGF-β signaling
por: Lee, Won Jai, et al.
Publicado: (2017)

Role of Telomeres and Telomeric Proteins in Human Malignancies and Their Therapeutic Potential
por: Fernandes, Stina George, et al.
Publicado: (2020)

Immediately transcripted genes in various hepatic ischemia models
por: Choi, Kang Kook, et al.
Publicado: (2012)

Telomere and Telomerase Therapeutics in Cancer
por: Xu, Yucheng, et al.
Publicado: (2016)

Therapeutic goal of diabetes mellitus
por: Wiwanitkit, Somsri, et al.
Publicado: (2011)

Disease clearance in ulcerative colitis: Setting the therapeutic goals for future in the treatment of ulcerative colitis
por: Ramos, Laura, et al.
Publicado: (2023)

Relaxin-expressing oncolytic adenovirus induces remodeling of physical and immunological aspects of cold tumor to potentiate PD-1 blockade
por: Jung, Bo-Kyeong, et al.
Publicado: (2020)

Telomeres in cancer therapy
por: Blasco, María A
Publicado: (2001)

Telomeric retrotransposons show propensity to form G-quadruplexes in various eukaryotic species
por: Jedlička, Pavel, et al.
Publicado: (2023)

Diabetes and Aging: From Treatment Goals to Pharmacologic Therapy
por: Longo, Miriam, et al.
Publicado: (2019)

Treatment-Free Remission: the New Goal in CML Therapy
por: Atallah, Ehab, et al.
Publicado: (2021)

Inotropes in goal-directed therapy: Do we need 'goals'?
por: Futier, Emmanuel, et al.
Publicado: (2010)

Telomeres and telomerase as therapeutic targets to prevent and treat age-related diseases
por: Bär, Christian, et al.
Publicado: (2016)

Telomeres and disease
por: Lansdorp, Peter M
Publicado: (2009)

Telomeres in disease
por: Calado, Rodrigo, et al.
Publicado: (2012)

Telomere as a Therapeutic Target in Dedifferentiated Liposarcoma
por: Alessandrini, Irene, et al.
Publicado: (2022)

Treatable traits and therapeutic targets: Goals for systems biology in infectious disease
por: Russell, Clark D., et al.
Publicado: (2017)

Shear bond strength of composite resin to titanium according to various surface treatments
por: Lee, Seung-Yun, et al.
Publicado: (2009)

Patient-Centered Goal Setting in Developmental Therapy: Discordance between Documented Goals and Caregiver-Perceived Goals
por: Angeli, Jennifer M., et al.
Publicado: (2019)

Cryopreserved Human Natural Killer Cells Exhibit Potent Antitumor Efficacy against Orthotopic Pancreatic Cancer through Efficient Tumor-Homing and Cytolytic Ability (Running Title: Cryopreserved NK Cells Exhibit Antitumor Effect)
por: Oh, Eonju, et al.
Publicado: (2019)

Erratum: Oh, E., et al. Cryopreserved Human Natural Killer Cells Exhibit Potent Antitumor Efficacy against Orthotopic Pancreatic Cancer through Efficient Tumor-Homing and Cytolytic Ability (Running Title: Cryopreserved NK Cells Exhibit Antitumor Effect). Cancers 2019, 11, 966
por: Oh, Eonju, et al.
Publicado: (2020)

The Therapeutic Goals Set by University Students in an Anonymous Web-Based Therapy and Support Setting
por: Hanley, Terry, et al.
Publicado: (2022)

The impact of comorbidity on medication adherence and therapeutic goals
por: Corsonello, A, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_4u2mt4bj5d9nkts19hi2s39524