Heterogeneity and Architecture of Pathological Prion Protein Assemblies: Time to Revisit the Molecular Basis of the Prion Replication Process?

Prions are proteinaceous infectious agents responsible for a range of neurodegenerative diseases in animals and humans. Prion particles are assemblies formed from a misfolded, β-sheet rich, aggregation-prone isoform (PrP(Sc)) of the host-encoded cellular prion protein (PrP(C)). Prions replicate by r...

Descripción completa

Detalles Bibliográficos
Autores principales: Igel-Egalon, Angélique, Bohl, Jan, Moudjou, Mohammed, Herzog, Laetitia, Reine, Fabienne, Rezaei, Human, Béringue, Vincent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563208/
https://www.ncbi.nlm.nih.gov/pubmed/31083283
http://dx.doi.org/10.3390/v11050429

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563208/
https://www.ncbi.nlm.nih.gov/pubmed/31083283
http://dx.doi.org/10.3390/v11050429

Ejemplares similares