Cargando…

Adeno-Associated Virus VP1u Exhibits Protease Activity

Adeno-associated viruses (AAVs) are being developed for gene delivery applications, with more than 100 ongoing clinical trials aimed at the treatment of monogenic diseases. In this study, the unique N-terminus of AAV capsid viral protein 1 (VP1u), containing a canonical group XIII PLA(2) enzyme doma...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kurian, Justin J., Lakshmanan, Renuk, Chmely, William M., Hull, Joshua A., Yu, Jennifer C., Bennett, Antonette, McKenna, Robert, Agbandje-McKenna, Mavis
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563295/ https://www.ncbi.nlm.nih.gov/pubmed/31035643 http://dx.doi.org/10.3390/v11050399

Ejemplares similares

Structural Dynamics and Activity of B19V VP1u during the pHs of Cell Entry and Endosomal Trafficking
por: Lakshmanan, Renuk V., et al.
Publicado: (2022)

Creating an arsenal of Adeno-associated virus (AAV) gene delivery stealth vehicles
por: Smith, J. Kennon, et al.
Publicado: (2018)

Adeno-associated virus capsid assembly is divergent and stochastic
por: Wörner, Tobias P., et al.
Publicado: (2021)

Mutants at the 2-Fold Interface of Adeno-associated Virus Type 2 (AAV2) Structural Proteins Suggest a Role in Viral Transcription for AAV Capsids
por: Aydemir, Fikret, et al.
Publicado: (2016)

Random Insertion of mCherry Into VP3 Domain of Adeno-associated Virus Yields Fluorescent Capsids With no Loss of Infectivity
por: Judd, Justin, et al.
Publicado: (2012)

Receptor Switching in Newly Evolved Adeno-associated Viruses
por: Havlik, L. Patrick, et al.
Publicado: (2021)

Mining the Protein Data Bank to Differentiate Error from Structural Variation in Clustered Static Structures: An Examination of HIV Protease
por: Venkatakrishnan, Balasubramanian, et al.
Publicado: (2012)

Improved Genome Packaging Efficiency of Adeno-associated Virus Vectors Using Rep Hybrids
por: Mietzsch, Mario, et al.
Publicado: (2021)

The Role of the Adeno-Associated Virus Capsid in Gene Transfer
por: Van Vliet, Kim M., et al.
Publicado: (2008)

Thermal Stability as a Determinant of AAV Serotype Identity
por: Bennett, Antonette, et al.
Publicado: (2017)

Adeno-Associated Virus (AAV) Capsid Stability and Liposome Remodeling During Endo/Lysosomal pH Trafficking
por: Lins-Austin, Bridget, et al.
Publicado: (2020)

Optimization of the Capsid of Recombinant Adeno-Associated Virus 2 (AAV2) Vectors: The Final Threshold?
por: Aslanidi, George V., et al.
Publicado: (2013)

X-ray crystallographic studies reveal that the incorporation of spacer groups in carbonic anhydrase inhibitors causes alternate binding modes
por: Fisher, S. Zoë, et al.
Publicado: (2006)

Mapping the AAV Capsid Host Antibody Response toward the Development of Second Generation Gene Delivery Vectors
por: Tseng, Yu-Shan, et al.
Publicado: (2014)

Adeno-associated Virus (AAV) Capsid Chimeras with Enhanced Infectivity Reveal a Core Element in the AAV Genome Critical for both Cell Transduction and Capsid Assembly
por: Viney, Lydia, et al.
Publicado: (2021)

Structural Characterization of Cuta- and Tusavirus: Insight into Protoparvoviruses Capsid Morphology
por: Mietzsch, Mario, et al.
Publicado: (2020)

Twenty-Five Years of Structural Parvovirology
por: Mietzsch, Mario, et al.
Publicado: (2019)

Sub-2 Å Ewald curvature corrected structure of an AAV2 capsid variant
por: Tan, Yong Zi, et al.
Publicado: (2018)

Completion of the AAV Structural Atlas: Serotype Capsid Structures Reveals Clade-Specific Features
por: Mietzsch, Mario, et al.
Publicado: (2021)

A simplified purification protocol for recombinant adeno-associated virus vectors
por: Potter, Mark, et al.
Publicado: (2014)

Atomic Resolution Structures of Human Bufaviruses Determined by Cryo-Electron Microscopy
por: Ilyas, Maria, et al.
Publicado: (2018)

Defining the Stoichiometry and Cargo Load of Viral and Bacterial Nanoparticles by Orbitrap Mass Spectrometry
por: Snijder, Joost, et al.
Publicado: (2014)

Tunable Protease-Activatable Virus Nanonodes
por: Judd, Justin, et al.
Publicado: (2014)

BAAV Transcytosis Requires an Interaction with β-1-4 Linked- Glucosamine and gp96
por: Di Pasquale, Giovanni, et al.
Publicado: (2010)

The Ins and Outs of Viral Infection: Keystone Meeting Review
por: Bird, Sara W., et al.
Publicado: (2014)

Production and characterization of an AAV1-VP3-only capsid: An analytical benchmark standard
por: Mietzsch, Mario, et al.
Publicado: (2023)

Endogenous amdoparvovirus-related elements reveal insights into the biology and evolution of vertebrate parvoviruses
por: Pénzes, Judit J, et al.
Publicado: (2018)

An Ancient Lineage of Highly Divergent Parvoviruses Infects both Vertebrate and Invertebrate Hosts
por: Pénzes, Judit J., et al.
Publicado: (2019)

Characterization of AAV-Specific Affinity Ligands: Consequences for Vector Purification and Development Strategies
por: Mietzsch, Mario, et al.
Publicado: (2020)

Coevolution of Adeno-associated Virus Capsid Antigenicity and Tropism through a Structure-Guided Approach
por: Havlik, L. Patrick, et al.
Publicado: (2020)

Optimizing the Targeting of Mouse Parvovirus 1 to Murine Melanoma Selects for Recombinant Genomes and Novel Mutations in the Viral Capsid Gene
por: Marr, Matthew, et al.
Publicado: (2018)

Capsid Structure of Aleutian Mink Disease Virus and Human Parvovirus 4: New Faces in the Parvovirus Family Portrait
por: Lakshmanan, Renuk, et al.
Publicado: (2022)

Rationally Engineered AAV Capsids Improve Transduction and Volumetric Spread in the CNS
por: Kanaan, Nicholas M., et al.
Publicado: (2017)

Germline viral “fossils” guide in silico reconstruction of a mid-Cenozoic era marsupial adeno-associated virus
por: Smith, Richard H., et al.
Publicado: (2016)

Atomic Resolution Structure of the Oncolytic Parvovirus LuIII by Electron Microscopy and 3D Image Reconstruction
por: Pittman, Nikéa, et al.
Publicado: (2017)

Diversity of environmental single-stranded DNA phages revealed by PCR amplification of the partial major capsid protein
por: Hopkins, Max, et al.
Publicado: (2014)

Characterization of the GBoV1 Capsid and Its Antibody Interactions
por: Yu, Jennifer Chun, et al.
Publicado: (2021)

Profiling of Glycan Receptors for Minute Virus of Mice in Permissive Cell Lines Towards Understanding the Mechanism of Cell Recognition
por: Halder, Sujata, et al.
Publicado: (2014)

Pediatric intraorbital abscess: Early recognition and management
por: McKenna, Dominic, et al.
Publicado: (2019)

Conference Report: WORKSHOP ON AGING, DIMENSIONAL STABILITY, AND DURABILITY ISSUES IN HIGH TECHNOLOGY POLYMERS Gaithersburg, MD May 28–29, 1992
por: Arnold-McKenna, Cynthia, et al.
Publicado: (1993)

Cannot write session to /tmp/vufind_sessions/sess_mt6b6rhd886i8kl284ecpjnjfb