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Invited Review: APOE at the interface of inflammation, neurodegeneration and pathological protein spread in Alzheimer's disease

Despite more than a century of research, the aetiology of sporadic Alzheimer's disease (AD) remains unclear and finding disease modifying treatments for AD presents one of the biggest medical challenges of our time. AD pathology is characterized by deposits of aggregated amyloid beta (Aβ) in am...

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Detalles Bibliográficos
Autores principales: Tzioras, M., Davies, C., Newman, A., Jackson, R., Spires‐Jones, T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563457/
https://www.ncbi.nlm.nih.gov/pubmed/30394574
http://dx.doi.org/10.1111/nan.12529