Chemoenzymatic Cascade Synthesis of Optically Pure Alkanoic Acids by Using Engineered Arylmalonate Decarboxylase Variants

Arylmalonate decarboxylase (AMDase) catalyzes the cofactor‐free asymmetric decarboxylation of prochiral arylmalonic acids and produces the corresponding monoacids with rigorous R selectivity. Alteration of catalytic cysteine residues and of the hydrophobic environment in the active site by protein e...

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Detalles Bibliográficos
Autores principales: Enoki, Junichi, Mügge, Carolin, Tischler, Dirk, Miyamoto, Kenji, Kourist, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563808/
https://www.ncbi.nlm.nih.gov/pubmed/30702787
http://dx.doi.org/10.1002/chem.201806339

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563808/
https://www.ncbi.nlm.nih.gov/pubmed/30702787
http://dx.doi.org/10.1002/chem.201806339

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