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Carbon metabolism modulates the efficacy of drugs targeting the cytochrome bc(1):aa(3) in Mycobacterium tuberculosis
The influence of carbon metabolism on oxidative phosphorylation is poorly understood in mycobacteria. M. tuberculosis expresses two respiratory terminal oxidases, the cytochrome bc(1):aa(3) and the cytochrome bd oxidase, which are jointly required for oxidative phosphorylation and mycobacterial viab...
Autores principales: | Kalia, Nitin P., Shi Lee, Bei, Ab Rahman, Nurlilah B., Moraski, Garrett C., Miller, Marvin J., Pethe, Kevin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6565617/ https://www.ncbi.nlm.nih.gov/pubmed/31197236 http://dx.doi.org/10.1038/s41598-019-44887-9 |
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