Parkinson’s disease protein DJ-1 regulates ATP synthase protein components to increase neuronal process outgrowth

Familial Parkinson’s disease (PD) protein DJ-1 mutations are linked to early onset PD. We have found that DJ-1 binds directly to the F(1)F(O) ATP synthase β subunit. DJ-1’s interaction with the β subunit decreased mitochondrial uncoupling and enhanced ATP production efficiency while in contrast muta...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Rongmin, Park, Han-A, Mnatsakanyan, Nelli, Niu, Yulong, Licznerski, Pawel, Wu, Jing, Miranda, Paige, Graham, Morven, Tang, Jack, Boon, Agnita J. W., Cossu, Giovanni, Mandemakers, Wim, Bonifati, Vincenzo, Smith, Peter J. S., Alavian, Kambiz N., Jonas, Elizabeth A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6565618/
https://www.ncbi.nlm.nih.gov/pubmed/31197129
http://dx.doi.org/10.1038/s41419-019-1679-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6565618/
https://www.ncbi.nlm.nih.gov/pubmed/31197129
http://dx.doi.org/10.1038/s41419-019-1679-x

Ejemplares similares