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Parkinson’s disease protein DJ-1 regulates ATP synthase protein components to increase neuronal process outgrowth

Familial Parkinson’s disease (PD) protein DJ-1 mutations are linked to early onset PD. We have found that DJ-1 binds directly to the F(1)F(O) ATP synthase β subunit. DJ-1’s interaction with the β subunit decreased mitochondrial uncoupling and enhanced ATP production efficiency while in contrast muta...

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Detalles Bibliográficos
Autores principales:	Chen, Rongmin, Park, Han-A, Mnatsakanyan, Nelli, Niu, Yulong, Licznerski, Pawel, Wu, Jing, Miranda, Paige, Graham, Morven, Tang, Jack, Boon, Agnita J. W., Cossu, Giovanni, Mandemakers, Wim, Bonifati, Vincenzo, Smith, Peter J. S., Alavian, Kambiz N., Jonas, Elizabeth A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6565618/ https://www.ncbi.nlm.nih.gov/pubmed/31197129 http://dx.doi.org/10.1038/s41419-019-1679-x

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