Robust elimination of genome-damaged cells safeguards against brain somatic aneuploidy following Knl1 deletion

The brain is a genomic mosaic shaped by cellular responses to genome damage. Here, we manipulate somatic genome stability by conditional Knl1 deletion from embryonic mouse brain. KNL1 mutations cause microcephaly and KNL1 mediates the spindle assembly checkpoint, a safeguard against chromosome misse...

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Detalles Bibliográficos
Autores principales: Shi, Lei, Qalieh, Adel, Lam, Mandy M., Keil, Jason M., Kwan, Kenneth Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6565622/
https://www.ncbi.nlm.nih.gov/pubmed/31197172
http://dx.doi.org/10.1038/s41467-019-10411-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6565622/
https://www.ncbi.nlm.nih.gov/pubmed/31197172
http://dx.doi.org/10.1038/s41467-019-10411-w

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