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Robust elimination of genome-damaged cells safeguards against brain somatic aneuploidy following Knl1 deletion
The brain is a genomic mosaic shaped by cellular responses to genome damage. Here, we manipulate somatic genome stability by conditional Knl1 deletion from embryonic mouse brain. KNL1 mutations cause microcephaly and KNL1 mediates the spindle assembly checkpoint, a safeguard against chromosome misse...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6565622/ https://www.ncbi.nlm.nih.gov/pubmed/31197172 http://dx.doi.org/10.1038/s41467-019-10411-w |