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Homeostatic pruning and activity of epidermal nerves are dysregulated in barrier-impaired skin during chronic itch development
The epidermal barrier is thought to protect sensory nerves from overexposure to environmental stimuli, and barrier impairment leads to pathological conditions associated with itch, such as atopic dermatitis (AD). However, it is not known how the epidermal barrier continuously protects nerves for the...
Autores principales: | Takahashi, Sonoko, Ishida, Azusa, Kubo, Akiharu, Kawasaki, Hiroshi, Ochiai, Sotaro, Nakayama, Manabu, Koseki, Haruhiko, Amagai, Masayuki, Okada, Takaharu |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6565750/ https://www.ncbi.nlm.nih.gov/pubmed/31197234 http://dx.doi.org/10.1038/s41598-019-44866-0 |
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