The Human TET2 Gene Contains Three Distinct Promoter Regions With Differing Tissue and Developmental Specificities

Tet methylcytosine dioxygenase 2 (TET2) is a tumor suppressor gene that is inactivated in a wide range of hematological cancers. TET2 enzymatic activity converts 5-methylcytosine (5-mC) into 5-hydroxymethylcytosine (5-hmC), an essential step in DNA demethylation. Human TET2 is highly expressed in pl...

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Detalles Bibliográficos
Autores principales: Lou, Hong, Li, Hongchuan, Ho, Kevin J., Cai, Luke L., Huang, Andy S., Shank, Tyler R., Verneris, Michael R., Nickerson, Michael L., Dean, Michael, Anderson, Stephen K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566030/
https://www.ncbi.nlm.nih.gov/pubmed/31231651
http://dx.doi.org/10.3389/fcell.2019.00099

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566030/
https://www.ncbi.nlm.nih.gov/pubmed/31231651
http://dx.doi.org/10.3389/fcell.2019.00099

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