Virtual Screening Guided Design, Synthesis and Bioactivity Study of Benzisoselenazolones (BISAs) on Inhibition of c-Met and Its Downstream Signalling Pathways

c-Met is a transmembrane receptor tyrosine kinase and an important therapeutic target for anticancer drugs. In this study, we designed a small library containing 300 BISAs molecules that consisted of carbohydrates, amino acids, isothiourea, tetramethylthiourea, guanidine and heterocyclic groups and...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Siqi, Song, Qiaoling, Wang, Xueting, Wei, Zhiqiang, Yu, Rilei, Wang, Xin, Jiang, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566228/
https://www.ncbi.nlm.nih.gov/pubmed/31137515
http://dx.doi.org/10.3390/ijms20102489

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566228/
https://www.ncbi.nlm.nih.gov/pubmed/31137515
http://dx.doi.org/10.3390/ijms20102489

Ejemplares similares