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Virtual Screening Guided Design, Synthesis and Bioactivity Study of Benzisoselenazolones (BISAs) on Inhibition of c-Met and Its Downstream Signalling Pathways

c-Met is a transmembrane receptor tyrosine kinase and an important therapeutic target for anticancer drugs. In this study, we designed a small library containing 300 BISAs molecules that consisted of carbohydrates, amino acids, isothiourea, tetramethylthiourea, guanidine and heterocyclic groups and...

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Detalles Bibliográficos
Autores principales:	Zhang, Siqi, Song, Qiaoling, Wang, Xueting, Wei, Zhiqiang, Yu, Rilei, Wang, Xin, Jiang, Tao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566228/ https://www.ncbi.nlm.nih.gov/pubmed/31137515 http://dx.doi.org/10.3390/ijms20102489

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