Novel Diamide-Based Benzenesulfonamides as Selective Carbonic Anhydrase IX Inhibitors Endowed with Antitumor Activity: Synthesis, Biological Evaluation and In Silico Insights

In this work, we present the synthesis and biological evaluation of novel series of diamide-based benzenesulfonamides 5a–h as inhibitors of the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1) isoforms hCA I, II, IX and XII. The target tumor-associated isoforms hCA IX and XII were undeniably the mo...

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Detalles Bibliográficos
Autores principales: Abdelrahman, Mohamed A., Eldehna, Wagdy M., Nocentini, Alessio, Bua, Silvia, Al-Rashood, Sara T., Hassan, Ghada S., Bonardi, Alessandro, Almehizia, Abdulrahman A., Alkahtani, Hamad M., Alharbi, Amal, Gratteri, Paola, Supuran, Claudiu T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566410/
https://www.ncbi.nlm.nih.gov/pubmed/31137489
http://dx.doi.org/10.3390/ijms20102484

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566410/
https://www.ncbi.nlm.nih.gov/pubmed/31137489
http://dx.doi.org/10.3390/ijms20102484

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