Kinase-Inactivated EGFR Is Required for the Survival of Wild-Type EGFR-Expressing Cancer Cells Treated with Tyrosine Kinase Inhibitors

Inhibiting the tyrosine kinase activity of epidermal growth factor receptor (EGFR) using small molecule tyrosine kinase inhibitors (TKIs) is often ineffective in treating cancers harboring wild-type EGFR (wt-EGFR). TKIs are known to cause dimerization of EGFR without altering its expression level. G...

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Detalles Bibliográficos
Autores principales: Thomas, Rintu, Srivastava, Shivangi, Katreddy, Rajasekhara Reddy, Sobieski, Jason, Weihua, Zhang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566606/
https://www.ncbi.nlm.nih.gov/pubmed/31121829
http://dx.doi.org/10.3390/ijms20102515

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566606/
https://www.ncbi.nlm.nih.gov/pubmed/31121829
http://dx.doi.org/10.3390/ijms20102515

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