Pharmacological Targeting of the ER-Resident Chaperones GRP94 or Cyclophilin B Induces Secretion of IL-22 Binding Protein Isoform-1 (IL-22BPi1)

Of the three interleukin-22 binding protein (IL-22BP) isoforms produced by the human IL22RA2 gene, IL-22BPi2 and IL-22BPi3 are capable of neutralizing IL-22. The longest isoform, IL-22BPi1, does not bind IL-22, is poorly secreted, and its retention within the endoplasmic reticulum (ER) is associated...

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Detalles Bibliográficos
Autores principales: Gómez-Fernández, Paloma, Urtasun, Andoni, Astobiza, Ianire, Mena, Jorge, Alloza, Iraide, Vandenbroeck, Koen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566634/
https://www.ncbi.nlm.nih.gov/pubmed/31108847
http://dx.doi.org/10.3390/ijms20102440

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566634/
https://www.ncbi.nlm.nih.gov/pubmed/31108847
http://dx.doi.org/10.3390/ijms20102440

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