Inhibition of N822K T>A mutation-induced constitutive c-KIT activation in AML cells triggers apoptotic and autophagic pathways leading to death

Background: The D816V mutation of c-KIT can constitutively activate tyrosine kinase, thereby promote core binding factor acute myeloid leukemia (CBF-AML) cell proliferation and inhibit apoptosis. Previous studies have indicated similar proliferation and apoptosis between N822K and D816V mutations.Th...

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Detalles Bibliográficos
Autores principales: Xu, Jianping, Zheng, Jinyuan, Fu, Xiaomeng, Wu, Wei, Tao, Linfen, Li, Dan, Lin, Donghong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566732/
https://www.ncbi.nlm.nih.gov/pubmed/31217744
http://dx.doi.org/10.7150/ijms.33532

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566732/
https://www.ncbi.nlm.nih.gov/pubmed/31217744
http://dx.doi.org/10.7150/ijms.33532

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