Synthesis and characterisation of a new benzamide-containing nitrobenzoxadiazole as a GSTP1-1 inhibitor endowed with high stability to metabolic hydrolysis

The antitumor agent 6-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)thio)hexan-1-ol (1) is a potent inhibitor of GSTP1-1, a glutathione S-transferase capable of inhibiting apoptosis by binding to JNK1 and TRAF2. We recently demonstrated that, unlike its parent compound, the benzoyl ester of 1 (compound 3)...

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Detalles Bibliográficos
Autores principales: Di Paolo, Veronica, Fulci, Chiara, Rotili, Dante, Sciarretta, Francesca, Lucidi, Alessia, Morozzo della Rocca, Blasco, De Luca, Anastasia, Rosato, Antonio, Quintieri, Luigi, Caccuri, Anna Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566875/
https://www.ncbi.nlm.nih.gov/pubmed/31169043
http://dx.doi.org/10.1080/14756366.2019.1617287

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566875/
https://www.ncbi.nlm.nih.gov/pubmed/31169043
http://dx.doi.org/10.1080/14756366.2019.1617287

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