Computational Studies on Water-Catalyzed Mechanisms for Stereoinversion of Glutarimide Intermediates Formed from Glutamic Acid Residues in Aqueous Phase

Aspartic acid (Asp) residues are prone to non-enzymatic stereoinversion, and Asp-residue stereoinversion is believed to be mediated via a succinimide (SI) intermediate. The stereoinverted Asp residues are believed to cause several age-related diseases. However, in peptides and proteins, few studies...

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Detalles Bibliográficos
Autores principales: Nakayoshi, Tomoki, Fukuyoshi, Shuichi, Kato, Koichi, Kurimoto, Eiji, Oda, Akifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567045/
https://www.ncbi.nlm.nih.gov/pubmed/31096657
http://dx.doi.org/10.3390/ijms20102410

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567045/
https://www.ncbi.nlm.nih.gov/pubmed/31096657
http://dx.doi.org/10.3390/ijms20102410

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