Antitumor activity of dual blockade of PD-L1 and MEK in NSCLC patients derived three-dimensional spheroid cultures

BACKGROUND: Anti-PD-1/PD-L1 drugs are effective as monotherapy in a proportion of NSCLC patients and there is a strong rationale for combining them with targeted therapy. Inhibition of MAPK pathway may have pleiotropic effects on the microenvironment. This work investigates the efficacy of combining...

Descripción completa

Detalles Bibliográficos
Autores principales: Della Corte, Carminia Maria, Barra, Giusi, Ciaramella, Vincenza, Di Liello, Raimondo, Vicidomini, Giovanni, Zappavigna, Silvia, Luce, Amalia, Abate, Marianna, Fiorelli, Alfonso, Caraglia, Michele, Santini, Mario, Martinelli, Erika, Troiani, Teresa, Ciardiello, Fortunato, Morgillo, Floriana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567578/
https://www.ncbi.nlm.nih.gov/pubmed/31196138
http://dx.doi.org/10.1186/s13046-019-1257-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567578/
https://www.ncbi.nlm.nih.gov/pubmed/31196138
http://dx.doi.org/10.1186/s13046-019-1257-1

Ejemplares similares