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Antitumor activity of dual blockade of PD-L1 and MEK in NSCLC patients derived three-dimensional spheroid cultures
BACKGROUND: Anti-PD-1/PD-L1 drugs are effective as monotherapy in a proportion of NSCLC patients and there is a strong rationale for combining them with targeted therapy. Inhibition of MAPK pathway may have pleiotropic effects on the microenvironment. This work investigates the efficacy of combining...
Autores principales: | Della Corte, Carminia Maria, Barra, Giusi, Ciaramella, Vincenza, Di Liello, Raimondo, Vicidomini, Giovanni, Zappavigna, Silvia, Luce, Amalia, Abate, Marianna, Fiorelli, Alfonso, Caraglia, Michele, Santini, Mario, Martinelli, Erika, Troiani, Teresa, Ciardiello, Fortunato, Morgillo, Floriana |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567578/ https://www.ncbi.nlm.nih.gov/pubmed/31196138 http://dx.doi.org/10.1186/s13046-019-1257-1 |
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