Synthetic-Evolution Reveals Narrow Paths to Regulation of the Saccharomyces cerevisiae Mitotic Kinesin-5 Cin8

Cdk1 has been found to phosphorylate the majority of its substrates in disordered regions, but some substrates maintain precise phosphosite positions over billions of years. Here, we examined the phosphoregulation of the kinesin-5, Cin8, using synthetic Cdk1-sites. We first analyzed the three native...

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Detalles Bibliográficos
Autores principales: Goldstein, Alina, Goldman, Darya, Valk, Ervin, Loog, Mart, Holt, Liam J., Gheber, Larisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567808/
https://www.ncbi.nlm.nih.gov/pubmed/31223274
http://dx.doi.org/10.7150/ijbs.30543

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567808/
https://www.ncbi.nlm.nih.gov/pubmed/31223274
http://dx.doi.org/10.7150/ijbs.30543

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