Deacylcynaropicrin Inhibits RANKL-Induced Osteoclastogenesis by Inhibiting NF-κB and MAPK and Promoting M2 Polarization of Macrophages

Inflammation can promote the maturity of osteoclasts and bone resorption in many bone disease such as osteoporosis and arthritis. Here, we aimed to investigate the inhibitory effects of deacylcynaropicrin (DAC) on osteoclastogenesis and bone resorption induced by RANKL. Bone-marrow-derived macrophag...

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Detalles Bibliográficos
Autores principales: Li, Zhikun, Zhu, Xiaodong, Xu, Ruijun, Wang, Yi, Hu, Ruixi, Xu, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567936/
https://www.ncbi.nlm.nih.gov/pubmed/31231214
http://dx.doi.org/10.3389/fphar.2019.00599

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567936/
https://www.ncbi.nlm.nih.gov/pubmed/31231214
http://dx.doi.org/10.3389/fphar.2019.00599

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