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Elucidating the Hot Spot Residues of Quorum Sensing Peptidic Autoinducer PapR by Multiple Amino Acid Replacements

The quorum sensing (QS) system of Bacillus cereus, an opportunistic human pathogen, utilizes the autoinducing PapR peptide signal that mediates the activation of the pleiotropic virulence regulator PlcR. A set of synthetic 7-mer PapR-derived peptides (PapR(7); ADLPFEF) have been shown to inhibit eff...

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Detalles Bibliográficos
Autores principales: Yehuda, Avishag, Slamti, Leyla, Malach, Einav, Lereclus, Didier, Hayouka, Zvi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6568020/
https://www.ncbi.nlm.nih.gov/pubmed/31231335
http://dx.doi.org/10.3389/fmicb.2019.01246