The Circadian Clock Gene Bmal1 Controls Intestinal Exporter MRP2 and Drug Disposition

The intestinal exporter MRP2 plays an important role in disposition and elimination of a wide range of drugs. Here, we aimed to clarify the impact of circadian clock on intestinal MRP2, and to determine the molecular mechanisms for generation of diurnal MRP2 expression. Methods: The regulatory effec...

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Detalles Bibliográficos
Autores principales: Yu, Fangjun, Zhang, Tianpeng, Zhou, Cui, Xu, Haiman, Guo, Lianxia, Chen, Min, Wu, Baojian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6568180/
https://www.ncbi.nlm.nih.gov/pubmed/31244920
http://dx.doi.org/10.7150/thno.33395

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6568180/
https://www.ncbi.nlm.nih.gov/pubmed/31244920
http://dx.doi.org/10.7150/thno.33395

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