Cargando…

The Circadian Clock Gene Bmal1 Controls Intestinal Exporter MRP2 and Drug Disposition

The intestinal exporter MRP2 plays an important role in disposition and elimination of a wide range of drugs. Here, we aimed to clarify the impact of circadian clock on intestinal MRP2, and to determine the molecular mechanisms for generation of diurnal MRP2 expression. Methods: The regulatory effec...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yu, Fangjun, Zhang, Tianpeng, Zhou, Cui, Xu, Haiman, Guo, Lianxia, Chen, Min, Wu, Baojian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6568180/ https://www.ncbi.nlm.nih.gov/pubmed/31244920 http://dx.doi.org/10.7150/thno.33395

Ejemplares similares

Deficiency of intestinal Bmal1 prevents obesity induced by high-fat feeding
por: Yu, Fangjun, et al.
Publicado: (2021)

Bmal1 regulates circadian expression of cytochrome P450 3a11 and drug metabolism in mice
por: Lin, Yanke, et al.
Publicado: (2019)

Small Heterodimer Partner Regulates Circadian Cytochromes p450 and Drug-Induced Hepatotoxicity
por: Zhang, Tianpeng, et al.
Publicado: (2018)

The Circadian Clock Gene BMAL1 Coordinates Intestinal Regeneration
por: Stokes, Kyle, et al.
Publicado: (2017)

Regulation of circadian clock transcriptional output by CLOCK:BMAL1
por: Trott, Alexandra J., et al.
Publicado: (2018)

Circadian Clock Gene Bmal1 Regulates Bilirubin Detoxification: A Potential Mechanism of Feedback Control of Hyperbilirubinemia
por: Wang, Shuai, et al.
Publicado: (2019)

BMAL1 dephosphorylation determines the pace of the circadian clock
por: Schibler, Ueli
Publicado: (2021)

Interaction of circadian clock proteins PER2 and CRY with BMAL1 and CLOCK
por: Langmesser, Sonja, et al.
Publicado: (2008)

Dysregulation of REV-ERBα impairs GABAergic function and promotes epileptic seizures in preclinical models
por: Zhang, Tianpeng, et al.
Publicado: (2021)

Opposite Carcinogenic Effects of Circadian Clock Gene BMAL1
por: Korkmaz, Tuba, et al.
Publicado: (2018)

The circadian clock component BMAL1 regulates osteogenesis in osseointegration
por: Deng, Shiyong, et al.
Publicado: (2022)

BMAL1 and CLOCK, Two Essential Components of the Circadian Clock, Are Involved in Glucose Homeostasis
por: Rudic, R. Daniel, et al.
Publicado: (2004)

Circadian clock gene Clock-Bmal1 regulates cellular senescence in Chronic obstructive pulmonary disease
por: Li, Lingling, et al.
Publicado: (2022)

Effects of BMAL1 Manipulation on the Brain’s Master Circadian Clock and Behavior
por: Haque, Samreen N., et al.
Publicado: (2019)

Deficiency of the Circadian Clock Gene Bmal1 Reduces Microglial Immunometabolism
por: Wang, Xiao-Lan, et al.
Publicado: (2020)

The Circadian Clock Gene, Bmal1, Regulates Intestinal Stem Cell Signaling and Represses Tumor Initiation
por: Stokes, Kyle, et al.
Publicado: (2021)

Protein phosphatase 4 controls circadian clock dynamics by modulating CLOCK/BMAL1 activity
por: Klemz, Sabrina, et al.
Publicado: (2021)

Circadian key component CLOCK/BMAL1 interferes with segmentation clock in mouse embryonic organoids
por: Umemura, Yasuhiro, et al.
Publicado: (2021)

BMAL1 LINKS THE CIRCADIAN CLOCK TO VIRAL AIRWAY PATHOLOGY AND ASTHMA PHENOTYPES
por: Ehlers, Anna, et al.
Publicado: (2017)

Association of circadian rhythm genes ARNTL/BMAL1 and CLOCK with multiple sclerosis
por: Lavtar, Polona, et al.
Publicado: (2018)

REGγ regulates circadian clock by modulating BMAL1 protein stability
por: Kubra, Syeda, et al.
Publicado: (2021)

Circadian Clock Component BMAL1 in the Paraventricular Nucleus Regulates Glucose Metabolism
por: Nakata, Masanori, et al.
Publicado: (2021)

Emerging Insight Into the Role of Circadian Clock Gene BMAL1 in Cellular Senescence
por: Zhang, Wenqian, et al.
Publicado: (2022)

The circadian clock gene Bmal1 facilitates cisplatin-induced renal injury and hepatization
por: Zha, Min, et al.
Publicado: (2020)

Dual modes of CLOCK:BMAL1 inhibition mediated by Cryptochrome and Period proteins in the mammalian circadian clock
por: Ye, Rui, et al.
Publicado: (2014)

NF-κB modifies the mammalian circadian clock through interaction with the core clock protein BMAL1
por: Shen, Yang, et al.
Publicado: (2021)

Ketamine Influences CLOCK:BMAL1 Function Leading to Altered Circadian Gene Expression
por: Bellet, Marina M., et al.
Publicado: (2011)

Interactive Organization of the Circadian Core Regulators PER2, BMAL1, CLOCK and PML
por: Miki, Takao, et al.
Publicado: (2016)

Insulin post-transcriptionally modulates Bmal1 protein to affect the hepatic circadian clock
por: Dang, Fabin, et al.
Publicado: (2016)

Potential Roles of Dec and Bmal1 Genes in Interconnecting Circadian Clock and Energy Metabolism
por: Sato, Fuyuki, et al.
Publicado: (2018)

The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication
por: Zhuang, Xiaodong, et al.
Publicado: (2019)

The Circadian Clock Gene Bmal1 Modulates Myometrium Contractile Function in Pregnant Mice
por: Van Quynh Duong, Thu, et al.
Publicado: (2021)

Circadian clock protein BMAL1 broadly influences autophagy and endolysosomal function in astrocytes
por: McKee, Celia A., et al.
Publicado: (2023)

“Defining the Independence of the Liver Circadian Clock” & “BMAL1-Driven Tissue Clocks Respond Independently to Light to Maintain Homeostasis”
por: Rotinen, Mirja
Publicado: (2020)

Cryptochrome 1 regulates the circadian clock through dynamic interactions with the BMAL1 C-terminus
por: Xu, Haiyan, et al.
Publicado: (2015)

A30 EPITHELIAL FUNCTION OF THE CIRCADIAN CLOCK GENE, BMAL1, IS NECESSARY FOR COLONIC REGENERATION
por: Taleb, Z, et al.
Publicado: (2023)

Selenium is a modulator of circadian clock that protects mice from the toxicity of a chemotherapeutic drug via upregulation of the core clock protein, BMAL1
por: Hu, Yan, et al.
Publicado: (2011)

Usf1, a suppressor of the circadian Clock mutant, reveals the nature of the DNA-binding of the CLOCK:BMAL1 complex in mice
por: Shimomura, Kazuhiro, et al.
Publicado: (2013)

E3 ubiquitin ligase HRD1 modulates the circadian clock through regulation of BMAL1 stability
por: Guo, Dongkai, et al.
Publicado: (2020)

PPAR-γ integrates obesity and adipocyte clock through epigenetic regulation of Bmal1
por: Wang, Shuai, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_0102qq5q9ppttju8geghqs6f90