Cargando…

DMPK gene DNA methylation levels are associated with muscular and respiratory profiles in DM1

OBJECTIVE: To assess the effects of dystrophia myotonica protein kinase (DMPK) DNA methylation (DNAme) epivariation on muscular and respiratory profiles in patients with myotonic dystrophy type 1 (DM1). METHODS: Phenotypes were assessed with standardized measures. Pyrosequencing of bisulfite-treated...

Descripción completa

Detalles Bibliográficos
Autores principales:	Légaré, Cécilia, Overend, Gayle, Guay, Simon-Pierre, Monckton, Darren G., Mathieu, Jean, Gagnon, Cynthia, Bouchard, Luigi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wolters Kluwer 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6568328/ https://www.ncbi.nlm.nih.gov/pubmed/31334355 http://dx.doi.org/10.1212/NXG.0000000000000338

Ejemplares similares

Acetylsalicylic acid, aging and coronary artery disease are associated with ABCA1 DNA methylation in men
por: Guay, Simon-Pierre, et al.
Publicado: (2014)

Sense and Antisense DMPK RNA Foci Accumulate in DM1 Tissues during Development
por: Michel, Lise, et al.
Publicado: (2015)

Variant repeats within the DMPK CTG expansion protect function in myotonic dystrophy type 1
por: Miller, Jacob N., et al.
Publicado: (2020)

Analysis of mutational dynamics at the DMPK (CTG)(n) locus identifies saliva as a suitable DNA sample source for genetic analysis in myotonic dystrophy type 1
por: Corrales, Eyleen, et al.
Publicado: (2019)

Muscular myopathies other than myotonic dystrophy also associated with (CTG)(n) expansion at the DMPK locus
por: Mohan, Vasavi, et al.
Publicado: (2012)

Genome Editing of Expanded CTG Repeats within the Human DMPK Gene Reduces Nuclear RNA Foci in the Muscle of DM1 Mice
por: Lo Scrudato, Mirella, et al.
Publicado: (2019)

Promising AAV.U7snRNAs vectors targeting DMPK improve DM1 hallmarks in patient-derived cell lines
por: Almeida, Camila F., et al.
Publicado: (2023)

DNA methylation signature of interleukin 1 receptor type II in asthma
por: Gagné-Ouellet, Valérie, et al.
Publicado: (2015)

Expanded DMPK repeats in dizygotic twins referred for diagnosis of autism versus absence of expanded DMPK repeats at screening of 330 children with autism
por: Musova, Zuzana, et al.
Publicado: (2016)

Placental Adiponectin Gene DNA Methylation Levels Are Associated With Mothers’ Blood Glucose Concentration
por: Bouchard, Luigi, et al.
Publicado: (2012)

Epigenetics of the myotonic dystrophy-associated DMPK gene neighborhood
por: Buckley, Lauren, et al.
Publicado: (2016)

Muscleblind1, but Not Dmpk or Six5, Contributes to a Complex Phenotype of Muscular and Motivational Deficits in Mouse Models of Myotonic Dystrophy
por: Matynia, Anna, et al.
Publicado: (2010)

Cooperation meets competition in microRNA-mediated DMPK transcript regulation
por: Koscianska, Edyta, et al.
Publicado: (2015)

DMPK mRNA Expression in Human Brain Tissue Throughout the Lifespan
por: Langbehn, Kathleen E., et al.
Publicado: (2020)

DMPK hypermethylation in sperm cells of myotonic dystrophy type 1 patients
por: Yanovsky-Dagan, Shira, et al.
Publicado: (2021)

Antiparasitic Sesquiterpenes from the Cameroonian Spice Scleria striatinux and Preliminary In Vitro and In Silico DMPK Assessment
por: Nyongbela, Kennedy D., et al.
Publicado: (2017)

Stable Longitudinal Methylation Levels at the CpG Sites Flanking the CTG Repeat of DMPK in Patients with Myotonic Dystrophy Type 1
por: Hildonen, Mathis, et al.
Publicado: (2020)

Role of Myotonic Dystrophy Protein Kinase (DMPK) in Glucose Homeostasis and Muscle Insulin Action
por: Llagostera, Esther, et al.
Publicado: (2007)

High Resolution Analysis of DMPK Hypermethylation and Repeat Interruptions in Myotonic Dystrophy Type 1
por: Rasmussen, Astrid, et al.
Publicado: (2022)

Myotonic dystrophy type 1 embryonic stem cells show decreased myogenic potential, increased CpG methylation at the DMPK locus and RNA mis-splicing
por: Franck, Silvie, et al.
Publicado: (2022)

Leptin and adiponectin DNA methylation levels in adipose tissues and blood cells are associated with BMI, waist girth and LDL-cholesterol levels in severely obese men and women
por: Houde, Andrée-Anne, et al.
Publicado: (2015)

Non-Alcoholic Steatohepatitis in Myotonic Dystrophy: DMPK Gene Mutation, Insulin Resistance and Development of Steatohepatitis
por: Bhardwaj, Rishi R., et al.
Publicado: (2010)

Targeting DMPK with Antisense Oligonucleotide Improves Muscle Strength in Myotonic Dystrophy Type 1 Mice
por: Jauvin, Dominic, et al.
Publicado: (2017)

DMPK is a New Candidate Mediator of Tumor Suppressor p53-Dependent Cell Death
por: Itoh, Katsuhiko, et al.
Publicado: (2019)

Human plasma pregnancy-associated miRNAs and their temporal variation within the first trimester of pregnancy
por: Légaré, Cécilia, et al.
Publicado: (2022)

DDX6 regulates sequestered nuclear CUG-expanded DMPK-mRNA in dystrophia myotonica type 1
por: Pettersson, Olof J., et al.
Publicado: (2014)

Expanded CUG repeats in DMPK transcripts adopt diverse hairpin conformations without influencing the structure of the flanking sequences
por: van Cruchten, Remco T.P., et al.
Publicado: (2019)

Repeat Interruptions Modify Age at Onset in Myotonic Dystrophy Type 1 by Stabilizing DMPK Expansions in Somatic Cells
por: Pešović, Jovan, et al.
Publicado: (2018)

Robust and accurate detection and sizing of repeats within the DMPK gene using a novel TP-PCR test
por: Leferink, Maike, et al.
Publicado: (2019)

Time-controlled and muscle-specific CRISPR/Cas9-mediated deletion of CTG-repeat expansion in the DMPK gene
por: Cardinali, Beatrice, et al.
Publicado: (2021)

Can remdesivir and its parent nucleoside GS-441524 be potential oral drugs? An in vitro and in vivo DMPK assessment
por: Xie, Jiashu, et al.
Publicado: (2021)

PPARGC1α gene DNA methylation variations in human placenta mediate the link between maternal hyperglycemia and leptin levels in newborns
por: Côté, Sandra, et al.
Publicado: (2016)

Mutant DMPK 3′-UTR transcripts disrupt C2C12 myogenic differentiation by compromising MyoD
por: Amack, Jeffrey D., et al.
Publicado: (2002)

Generation of KCL018 research grade human embryonic stem cell line carrying a mutation in the DMPK gene
por: Miere, Cristian, et al.
Publicado: (2016)

The Perspective of DMPK on Recombinant Adeno-Associated Virus-Based Gene Therapy: Past Learning, Current Support, and Future Contribution
por: Chen, Nancy, et al.
Publicado: (2022)

Specific DMPK-promoter targeting by CRISPRi reverses myotonic dystrophy type 1-associated defects in patient muscle cells
por: Porquet, Florent, et al.
Publicado: (2023)

The DM-scope registry: a rare disease innovative framework bridging the gap between research and medical care
por: De Antonio, Marie, et al.
Publicado: (2019)

Anticancer Activity of Ganoderic Acid DM: Current Status and Future Perspective
por: Bryant, John Matthew, et al.
Publicado: (2017)

Analysis of CTG repeat length variation in the DMPK gene in the general population and the molecular diagnosis of myotonic dystrophy type 1 in Malaysia
por: Ambrose, Kathlin K, et al.
Publicado: (2017)

Identification, molecular characterization and segregation analysis of a variant DMPK pre-mutation allele in a three-generation Italian family
por: Fontana, Luana, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_iu4rctdd7s87aitrg82qk2mpmb