Enhanced immunogenicity of a functional enzyme by T cell epitope modification

BACKGROUND: T helper epitopes are necessary for the induction of high titers of antigen-specific IgG antibodies. We are interested in the epitope modification of intact proteins as a method to enhance their immunogenicity for the generation of recombinant protein-based vaccines. RESULTS: Hartley str...

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Detalles Bibliográficos
Autores principales: Mucha, Jeanette M, Stickler, Marcia M, Poulose, AJ, Ganshaw, Grant, Saldajeno, Mae, Collier, Kathy, Huang, Manley T, Harding, Fiona A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2002
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC65700/
https://www.ncbi.nlm.nih.gov/pubmed/11869454
http://dx.doi.org/10.1186/1471-2172-3-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC65700/
https://www.ncbi.nlm.nih.gov/pubmed/11869454
http://dx.doi.org/10.1186/1471-2172-3-2

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