Comprehensive substrate specificity profiling of the human Nek kinome reveals unexpected signaling outputs

Human NimA-related kinases (Neks) have multiple mitotic and non-mitotic functions, but few substrates are known. We systematically determined the phosphorylation-site motifs for the entire Nek kinase family, except for Nek11. While all Nek kinases strongly select for hydrophobic residues in the −3 p...

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Detalles Bibliográficos
Autores principales: van de Kooij, Bert, Creixell, Pau, van Vlimmeren, Anne, Joughin, Brian A, Miller, Chad J, Haider, Nasir, Simpson, Craig D, Linding, Rune, Stambolic, Vuk, Turk, Benjamin E, Yaffe, Michael B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6570481/
https://www.ncbi.nlm.nih.gov/pubmed/31124786
http://dx.doi.org/10.7554/eLife.44635

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6570481/
https://www.ncbi.nlm.nih.gov/pubmed/31124786
http://dx.doi.org/10.7554/eLife.44635

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