Catechol-o-methyltransferase inhibitor tolcapone improves learning and memory in naïve but not in haloperidol challenged rats

OBJECTIVE(S): Dopamine plays an important role in cognitive functions. Inhibition of the dopamine-degrading enzyme catechol-O-methyltransferase (COMT) may have beneficial effects. Our aim was to assess the effect of COMT inhibitor tolcapone (TCP) on learning and memory in naïve and haloperidol-chall...

Descripción completa

Detalles Bibliográficos
Autores principales: Mihaylova, Anita, Zlatanova, Hristina, Doncheva, Nina, Delev, Delian, Kostadinov, Ilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mashhad University of Medical Sciences 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6570742/
https://www.ncbi.nlm.nih.gov/pubmed/31231499
http://dx.doi.org/10.22038/ijbms.2019.33025.7890

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6570742/
https://www.ncbi.nlm.nih.gov/pubmed/31231499
http://dx.doi.org/10.22038/ijbms.2019.33025.7890

Ejemplares similares