Dihydromyricetin and Salvianolic acid B inhibit alpha-synuclein aggregation and enhance chaperone-mediated autophagy

BACKGROUND: Progressive accumulation of α-synuclein is a key step in the pathological development of Parkinson’s disease. Impaired protein degradation and increased levels of α-synuclein may trigger a pathological aggregation in vitro and in vivo. The chaperone-mediated autophagy (CMA) pathway is in...

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Detalles Bibliográficos
Autores principales: Wu, Jia-Zhen, Ardah, Mustafa, Haikal, Caroline, Svanbergsson, Alexander, Diepenbroek, Meike, Vaikath, Nishant N., Li, Wen, Wang, Zhan-You, Outeiro, Tiago F., El-Agnaf, Omar M., Li, Jia-Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6570948/
https://www.ncbi.nlm.nih.gov/pubmed/31223479
http://dx.doi.org/10.1186/s40035-019-0159-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6570948/
https://www.ncbi.nlm.nih.gov/pubmed/31223479
http://dx.doi.org/10.1186/s40035-019-0159-7

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