Cargando…

Dihydromyricetin and Salvianolic acid B inhibit alpha-synuclein aggregation and enhance chaperone-mediated autophagy

BACKGROUND: Progressive accumulation of α-synuclein is a key step in the pathological development of Parkinson’s disease. Impaired protein degradation and increased levels of α-synuclein may trigger a pathological aggregation in vitro and in vivo. The chaperone-mediated autophagy (CMA) pathway is in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Jia-Zhen, Ardah, Mustafa, Haikal, Caroline, Svanbergsson, Alexander, Diepenbroek, Meike, Vaikath, Nishant N., Li, Wen, Wang, Zhan-You, Outeiro, Tiago F., El-Agnaf, Omar M., Li, Jia-Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6570948/ https://www.ncbi.nlm.nih.gov/pubmed/31223479 http://dx.doi.org/10.1186/s40035-019-0159-7

Ejemplares similares

The Bacterial Amyloids Phenol Soluble Modulins from Staphylococcus aureus Catalyze Alpha-Synuclein Aggregation
por: Haikal, Caroline, et al.
Publicado: (2021)

Inhibition of alpha-synuclein seeded fibril formation and toxicity by herbal medicinal extracts
por: Ardah, Mustafa T., et al.
Publicado: (2020)

Monitoring the interactions between alpha-synuclein and Tau in vitro and in vivo using bimolecular fluorescence complementation
por: Torres-Garcia, Laura, et al.
Publicado: (2022)

Structural and Biophysical Characterization of Stable Alpha-Synuclein Oligomers
por: Vaikath, Nishant, et al.
Publicado: (2022)

Natural Alkaloid Compounds as Inhibitors for Alpha-Synuclein Seeded Fibril Formation and Toxicity
por: Ghanem, Simona S., et al.
Publicado: (2021)

Age-dependent alpha-synuclein accumulation and aggregation in the colon of a transgenic mouse model of Parkinson’s disease
por: Chen, Qian-Qian, et al.
Publicado: (2018)

Small Molecule Fisetin Modulates Alpha–Synuclein Aggregation
por: Rosado-Ramos, Rita, et al.
Publicado: (2021)

Oligomeric and phosphorylated alpha-synuclein as potential CSF biomarkers for Parkinson’s disease
por: Majbour, Nour K., et al.
Publicado: (2016)

Assessment of Aggregated and Exosome-Associated α-Synuclein in Brain Tissue and Cerebrospinal Fluid Using Specific Immunoassays
por: Anagnostou, Dimitrios, et al.
Publicado: (2023)

Alpha-Synuclein Antibody Characterization: Why Semantics Matters
por: Outeiro, Tiago Fleming
Publicado: (2021)

Endogenous Levels of Alpha-Synuclein Modulate Seeding and Aggregation in Cultured Cells
por: Vasili, Eftychia, et al.
Publicado: (2022)

Fibrillar form of α-synuclein-specific scFv antibody inhibits α-synuclein seeds induced aggregation and toxicity
por: Gupta, Vijay, et al.
Publicado: (2020)

FRET-Based Screening Identifies p38 MAPK and PKC Inhibition as Targets for Prevention of Seeded α-Synuclein Aggregation
por: Svanbergsson, Alexander, et al.
Publicado: (2021)

Increased levels of CSF total but not oligomeric or phosphorylated forms of alpha-synuclein in patients diagnosed with probable Alzheimer’s disease
por: Majbour, Nour K., et al.
Publicado: (2017)

Novel engineered nanobodies specific for N‐terminal region of alpha‐synuclein recognize Lewy‐body pathology and inhibit in‐vitro seeded aggregation and toxicity
por: Hmila, Issam, et al.
Publicado: (2022)

Alpha-Synuclein: Mechanisms of Release and Pathology Progression in Synucleinopathies
por: Brás, Inês C., et al.
Publicado: (2021)

The effects of the novel A53E alpha-synuclein mutation on its oligomerization and aggregation
por: Lázaro, Diana F., et al.
Publicado: (2016)

Assessing the Subcellular Dynamics of Alpha-synuclein Using Photoactivation Microscopy
por: Gonçalves, Susana, et al.
Publicado: (2013)

A novel multiplex assay for simultaneous quantification of total and S129 phosphorylated human alpha-synuclein
por: Landeck, Natalie, et al.
Publicado: (2016)

SUMOylation of Alpha-Synuclein Influences on Alpha-Synuclein Aggregation Induced by Methamphetamine
por: Zhu, Lin-nan, et al.
Publicado: (2018)

The Interplay between Alpha-Synuclein Clearance and Spreading
por: Lopes da Fonseca, Tomás, et al.
Publicado: (2015)

α-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity
por: Ghanem, Simona S., et al.
Publicado: (2022)

Differential seeding and propagating efficiency of α-synuclein strains generated in different conditions
por: Liu, Di, et al.
Publicado: (2021)

Systematic Comparison of the Effects of Alpha-synuclein Mutations on Its Oligomerization and Aggregation
por: Lázaro, Diana F., et al.
Publicado: (2014)

Phosphorylated exogenous alpha-synuclein fibrils exacerbate pathology and induce neuronal dysfunction in mice
por: Karampetsou, Mantia, et al.
Publicado: (2017)

Production of Recombinant Alpha-Synuclein: Still No Standardized Protocol in Sight
por: Al-Azzani, Mohammed, et al.
Publicado: (2022)

The Molecular Chaperone DNAJB6, but Not DNAJB1, Suppresses the Seeded Aggregation of Alpha-Synuclein in Cells
por: Deshayes, Natasja, et al.
Publicado: (2019)

Alpha-Synuclein Glycation and the Action of Anti-Diabetic Agents in Parkinson’s Disease
por: König, Annekatrin, et al.
Publicado: (2018)

DJ-1 Inhibits α-Synuclein Aggregation by Regulating Chaperone-Mediated Autophagy
por: Xu, Chuan-Ying, et al.
Publicado: (2017)

ATP13A2 and Alpha-synuclein: a Metal Taste in Autophagy
por: Lopes da Fonseca, Tomás, et al.
Publicado: (2014)

Alpha-synuclein: from secretion to dysfunction and death
por: Marques, O, et al.
Publicado: (2012)

Expression, purification and characterization of α-synuclein fibrillar specific scFv from inclusion bodies
por: Gupta, Vijay, et al.
Publicado: (2020)

Inhibition of HDAC6 activity protects dopaminergic neurons from alpha-synuclein toxicity
por: Francelle, Laetitia, et al.
Publicado: (2020)

RT-QuIC Using C-Terminally Truncated α-Synuclein Forms Detects Differences in Seeding Propensity of Different Brain Regions from Synucleinopathies
por: Poggiolini, Ilaria, et al.
Publicado: (2021)

Ellagic Acid Prevents α-Synuclein Aggregation and Protects SH-SY5Y Cells from Aggregated α-Synuclein-Induced Toxicity via Suppression of Apoptosis and Activation of Autophagy
por: Ardah, Mustafa T, et al.
Publicado: (2021)

Genipin prevents alpha-synuclein aggregation and toxicity by affecting endocytosis, metabolism and lipid storage
por: Rosado-Ramos, Rita, et al.
Publicado: (2023)

Alpha-Synuclein Aggregation in Parkinson's Disease
por: Srinivasan, E., et al.
Publicado: (2021)

Mutation of Tyrosine Sites in the Human Alpha-Synuclein Gene Induces Neurotoxicity in Transgenic Mice with Soluble Alpha-Synuclein Oligomer Formation
por: Lassen, Louise Berkhoudt, et al.
Publicado: (2022)

Dopamine-Induced Conformational Changes in Alpha-Synuclein
por: Outeiro, Tiago F., et al.
Publicado: (2009)

Alpha-Synuclein FRET Biosensors Reveal Early Alpha-Synuclein Aggregation in the Endoplasmic Reticulum
por: Miraglia, Fabiana, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_0qvmno9s420gppfiq4om941nr7