Capsazepine prolongation of the duration of lidocaine block of sensory transmission in mice may be mediated by modulation of HCN channel currents

BACKGROUND AND OBJECTIVES: Hyperpolarization-activation cyclic nucleotide-gated (HCN) channels contribute to the effects of lidocaine. Capsazepine (CPZ), a competitive inhibitor of capsaicin of transient receptor potential vanilloid-1 channel, has also been found to inhibit HCN channel currents (I(h...

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Detalles Bibliográficos
Autores principales: Zhao, Wenling, Liang, Peng, Liu, Jin, Li, Huan, Liao, Daqing, Chen, Xiangdong, Li, Qian, Zhou, Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6571133/
https://www.ncbi.nlm.nih.gov/pubmed/31223538
http://dx.doi.org/10.7717/peerj.7111

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6571133/
https://www.ncbi.nlm.nih.gov/pubmed/31223538
http://dx.doi.org/10.7717/peerj.7111

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