Discovery of Cisplatin Binding to Thymine and Cytosine on a Single-Stranded Oligodeoxynucleotide by High Resolution FT-ICR Mass Spectrometry

The clinically widely-used anticancer drug, cisplatin, binds strongly to DNA as a DNA-damaging agent. Herein, we investigated the interaction of cisplatin with a 15-mer single-stranded C,T-rich oligodeoxynucleotide, 5′-CCTT(4)CTT(7)G(8)C(9)T(10)TCTCC-3′ (ODN15), using ultra-high resolution Fourier t...

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Detalles Bibliográficos
Autores principales: Zeng, Wenjuan, Zhang, Yanyan, Zheng, Wei, Luo, Qun, Han, Juanjuan, Liu, Jian’an, Zhao, Yao, Jia, Feifei, Wu, Kui, Wang, Fuyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6571787/
https://www.ncbi.nlm.nih.gov/pubmed/31091778
http://dx.doi.org/10.3390/molecules24101852

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6571787/
https://www.ncbi.nlm.nih.gov/pubmed/31091778
http://dx.doi.org/10.3390/molecules24101852

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